Tullio Florio Selected Research

rat CLIC1 protein

2/2022	Chloride intracellular channel 1 activity is not required for glioblastoma development but its inhibition dictates glioma stem cell responsivity to novel biguanide derivatives.
1/2018	Inhibition of Chloride Intracellular Channel 1 (CLIC1) as Biguanide Class-Effect to Impair Human Glioblastoma Stem Cell Viability.
10/2015	Chloride channels in cancer: Focus on chloride intracellular channel 1 and 4 (CLIC1 AND CLIC4) proteins in tumor development and as novel therapeutic targets.

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Tullio Florio Research Topics

Disease

77	Neoplasms (Cancer) 11/2023 - 04/2003
26	Glioblastoma (Glioblastoma Multiforme) 09/2023 - 04/2003
14	Pituitary Neoplasms (Pituitary Adenoma) 01/2020 - 10/2002
13	Neuroblastoma 06/2021 - 02/2002
13	Prion Diseases (Transmissible Spongiform Encephalopathies) 11/2019 - 02/2002
12	Alzheimer Disease (Alzheimer's Disease) 01/2020 - 12/2006
11	Glioma (Gliomas) 02/2022 - 07/2004
8	Neuroendocrine Tumors (Neuroendocrine Tumor) 08/2019 - 01/2008
6	Meningioma (Meningiomas) 11/2023 - 01/2004
6	Adenoma (Adenomas) 01/2020 - 10/2002
6	Carcinogenesis 01/2020 - 01/2010
6	Brain Neoplasms (Brain Tumor) 01/2020 - 11/2002
5	Inflammation (Inflammations) 02/2024 - 11/2002
5	Scrapie 01/2022 - 12/2007
5	Neurodegenerative Diseases (Neurodegenerative Disease) 02/2019 - 01/2012
4	Breast Neoplasms (Breast Cancer) 01/2018 - 01/2008
4	Malignant Mesothelioma 01/2017 - 08/2011
3	Neoplasm Metastasis (Metastasis) 12/2020 - 08/2005
3	Tics (Tic) 01/2017 - 03/2009
3	Mesothelioma 01/2017 - 03/2010
3	Growth Hormone-Secreting Pituitary Adenoma 01/2016 - 07/2003
3	Gliosis 11/2007 - 04/2003
2	Thyroid Neoplasms (Thyroid Cancer) 01/2023 - 01/2021
2	Primitive Neuroectodermal Tumors (PNET) 06/2017 - 10/2014
2	Brain Diseases (Brain Disorder) 01/2016 - 01/2007
2	Infections 01/2014 - 11/2002
2	Amyloid Plaque 01/2012 - 01/2007
2	Ovarian Neoplasms (Ovarian Cancer) 01/2010 - 08/2005

Drug/Important Bio-Agent (IBA)

18	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2004
17	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 04/2018 - 07/2003
15	Prion ProteinsIBA 01/2022 - 02/2002
14	Metformin (Glucophage)FDA LinkGeneric 02/2024 - 01/2013
13	LigandsIBA 04/2021 - 11/2002
13	Peptides (Polypeptides)IBA 01/2020 - 04/2003
12	ChemokinesIBA 10/2023 - 04/2003
12	Amyloid (Amyloid Fibrils)IBA 01/2020 - 12/2006
11	Somatostatin Receptors (Somatostatin Receptor)IBA 04/2021 - 05/2003
10	Protein Isoforms (Isoforms)IBA 06/2021 - 10/2002
9	Chemokine ReceptorsIBA 12/2020 - 11/2002
9	Messenger RNA (mRNA)IBA 02/2017 - 04/2003
8	Chemokine CXCL12IBA 10/2023 - 11/2002
7	Octreotide (Sandostatin)FDA LinkGeneric 04/2021 - 02/2006
6	Cisplatin (Platino)FDA LinkGeneric 06/2021 - 01/2015
6	CXCR4 Receptors (CXCR4 Receptor)IBA 01/2014 - 11/2002
5	Peptide Hydrolases (Proteases)FDA Link 01/2022 - 02/2002
5	Growth Hormone (Somatotropin)IBA 04/2021 - 10/2002
5	Phosphotransferases (Kinase)IBA 02/2013 - 04/2003
5	DNA (Deoxyribonucleic Acid)IBA 08/2008 - 07/2003
4	Hormones (Hormone)IBA 01/2020 - 07/2003
4	Sorafenib (BAY 43-9006)FDA Link 01/2018 - 02/2013
4	Hypoglycemic Agents (Hypoglycemics)IBA 01/2018 - 04/2015
4	Protein Tyrosine PhosphatasesIBA 02/2017 - 07/2004
4	Amyloid beta-PeptidesIBA 05/2007 - 12/2006
4	ThymidineIBA 01/2007 - 07/2003
3	Immune Checkpoint InhibitorsIBA 02/2022 - 12/2020
3	rat CLIC1 proteinIBA 02/2022 - 10/2015
3	ChloridesIBA 02/2022 - 11/2014
3	BiguanidesIBA 02/2022 - 01/2018
3	PrionsIBA 01/2022 - 01/2007
3	pasireotideIBA 04/2021 - 10/2014
3	Antineoplastic Agents (Antineoplastics)IBA 01/2018 - 01/2013
3	RNA (Ribonucleic Acid)IBA 01/2017 - 10/2010
3	NestinIBA 01/2017 - 03/2009
3	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2017 - 12/2006
3	Untranslated RNA (Noncoding RNA)IBA 12/2015 - 02/2011
3	Gefitinib (Iressa)FDA Link 03/2010 - 01/2008
3	ErbB Receptors (EGF Receptor)IBA 03/2009 - 08/2005
3	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 01/2007 - 10/2002
2	CytokinesIBA 11/2023 - 01/2017
2	Acetazolamide (Diamox)FDA LinkGeneric 06/2021 - 11/2020
2	FendilineIBA 06/2021 - 11/2020
2	tau Proteins (tau Protein)IBA 01/2020 - 01/2012
2	Transcription Factors (Transcription Factor)IBA 01/2020 - 11/2002
2	Growth Factor ReceptorsIBA 11/2019 - 01/2013
2	Histone Deacetylase InhibitorsIBA 05/2019 - 01/2016
2	Chloride Channels (Chloride Channel)IBA 01/2019 - 10/2015
2	Ion Channels (Ion Channel)IBA 01/2019 - 10/2015
2	Membrane Proteins (Integral Membrane Proteins)IBA 11/2018 - 10/2015
2	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2018 - 01/2007
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2018 - 11/2011
2	Epidermal Growth Factor (EGF)IBA 01/2017 - 03/2010
2	Dopamine (Intropin)FDA LinkGeneric 01/2017 - 06/2008
2	Interleukin-8 (Interleukin 8)IBA 01/2017 - 12/2006
2	LipopolysaccharidesIBA 11/2016 - 04/2003
2	Differentiation AntigensIBA 12/2015 - 07/2012
2	Temozolomide (Temodar)FDA LinkGeneric 01/2015 - 01/2015
2	Thyrotropin (Thyroid-Stimulating Hormone)FDA Link 03/2012 - 06/2011
2	Cabergoline FDA LinkGeneric 06/2011 - 06/2008
2	somatostatin receptor type 1IBA 11/2009 - 07/2003
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 03/2009 - 07/2003
2	phosphotyrosine phosphatase etaIBA 09/2008 - 12/2004
2	PresenilinsIBA 05/2007 - 01/2007
2	2- (2- amino- 3- methoxyphenyl)- 4H- 1- benzopyran- 4- oneIBA 01/2007 - 12/2006
2	CXC ChemokinesIBA 10/2006 - 11/2002
2	Bovine Serum AlbuminIBA 07/2003 - 04/2003

Therapy/Procedure

35	Therapeutics 11/2023 - 01/2004
9	Drug Therapy (Chemotherapy) 11/2023 - 01/2010
4	Radiotherapy 03/2016 - 05/2012
2	Precision Medicine 02/2022 - 12/2020
2	Combined Modality Therapy 01/2015 - 01/2014